Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded
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منابع مشابه
Abnormalities in neuromuscular junction structure and skeletal muscle function in mice lacking the P2X2 nucleotide receptor.
ATP is co-released in significant quantities with acetylcholine from motor neurons at skeletal neuromuscular junctions (NMJ). However, the role of this neurotransmitter in muscle function remains unclear. The P2X2 ion channel receptor subunit is expressed during development of the skeletal NMJ, but not in adult muscle fibers, although it is re-expressed during muscle fiber regeneration. Using m...
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Testicular orphan nuclear receptor 4 (TR4) is a member of the nuclear receptor superfamily for which a ligand has not yet been found. In vitro data obtained from various cell lines suggest that TR4 functions as a master regulator to modulate many signaling pathways, yet the in vivo physiological roles of TR4 remain unclear. Here, we report the generation of mice lacking TR4 by means of targeted...
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Glial cell line-derived neurotrophic factor (GDNF) and a related protein, neurturin (NTN), require a GPI-linked coreceptor, either GFR alpha1 or GFR alpha2, for signaling via the transmembrane Ret tyrosine kinase. We show that mice lacking functional GFR alpha2 coreceptor (Gfra2-/-) are viable and fertile but have dry eyes and grow poorly after weaning, presumably due to malnutrition. While the...
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The rev-erbAalpha orphan protein belongs to the steroid nuclear receptor superfamily. No ligand has been identified for this protein, and little is known of its function in development or physiology. In this study, we focus on 1) the distribution of the rev-erbAalpha protein in adult fast- and slow-twitch skeletal muscles and muscle fibers and 2) how the rev-erbAalpha protein influences myosin ...
متن کاملAberrant expression of myosin isoforms in skeletal muscles from mice lacking the rev-erbA orphan receptor gene
Pircher, P., P. Chomez, F. Yu, B. Vennström, and L. Larsson. Aberrant expression of myosin isoforms in skeletal muscles from mice lacking the rev-erbA orphan receptor gene. Am J Physiol Regul Integr Comp Physiol 288: R482–R490, 2005. First published September 16, 2004; doi:10.1152/ajpregu.00690.2003.—The rev-erbA orphan protein belongs to the steroid nuclear receptor superfamily. No ligand has ...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2010
ISSN: 1058-8388
DOI: 10.1002/dvdy.22362